Abstract #1918

T2 mapping with GRAPPATINI for the characterization of adult-onset and juvenile-onset Huntington Disease

Maria Eugenia Caligiuri¹, Maria Celeste Bonacci¹, Tobias Kober², Domenico Zacà³, Ferdinando Squitieri^4,5, Aldo Quattrone¹, and Umberto Sabatini¹

¹Neuroscience Research Center, Università degli Studi Magna Graecia di Catanzaro, Catanzaro, Italy, ²Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ³Siemens Healthcare, Milan, Italy, ⁴Italian League for Research on Huntington Disease, Rome, Italy, ⁵IRCSS Casa Sollievo della Sofferenza/CSS-Mendel, Rome, Italy

Synopsis

Keywords: Neurodegeneration, Rare disease, Huntington DiseaseT2 mapping is a quantitative MRI technique that may provide further insight regarding the changes that differentially underlie Huntington Disease in two of its clinical forms, adult-onset and juvenile-onset. Here we present pilot evidence that the study of T2 properties of the brain might be of great benefit to the research focused on this rare disease.

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