Abstract #1919

Blood-brain barrier permeability changes over the lifespan

Beatriz Padrela¹, Markus H Sneve², Sanne Zelhorst¹, Mervin Tee³, Amnah Mahroo⁴, Joost Kuijer¹, Kristine Walhovd², Simon Konstandin⁴, Klaus Eickel^4,5, Frederik Barkhof^1,6, Saima Hilal³, Matthias Günther⁴, Henk J.M.M. Mutsaerts¹, and Jan Petr⁷

¹Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, ²Department of Psychology, Center for Lifespan Changes in Brain and Cognition, Oslo, Norway, ³National University of Singapore and National University Health System, Saw Swee Hock School of Public Health, Singapore, Singapore, ⁴Fraunhofer-Insitute for Digital Medicine MEVIS, Bremen, Germany, ⁵mediri GmbH, Heidelberg, Germany, ⁶University College London, Queen Square Institute of Neurology and Centre for Medical Image Computing (CMIC), London, United Kingdom, ⁷Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

Synopsis

Keywords: Neurodegeneration, Arterial spin labelling, Blood-brain barrierBlood-brain-barrier (BBB) dysfunction is a hallmark of aging-related disorders, including cerebral small vessel disease and Alzheimer’s disease. An emerging biomarker of BBB dysfunction is time of exchange (Tex) of water across the BBB as measured by multi-echo arterial spin labeling MRI. We evaluated Tex across the age spectrum in 40 adults from two cohorts of healthy controls, and demonstrated that Tex is higher in gray than in white matter, higher in females than in males, and that Tex decreases with age. These findings suggest that BBB permeability changes over the lifespan can be investigated using arterial spin labeling approaches.

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