Keywords: Neurodegeneration, Microstructure, amyotrophic lateral sclerosis - ALSAmyotrophic lateral sclerosis (ALS) is a fatal upper and lower motor neuron degradation disease that leads to progressive myofiber abnormalities (e.g., decreased size and distribution). The relaxivity contrast imaging (RCI) parameter, TRATE (tissue transverse relaxivity at tracer equilibrium), has been shown to decrease during ALS induced myofiber degradation. The goal of this study is to expand a validated computational method to investigate the biophysical basis of TRATE in muscles of ALS patients and to optimize RCI acquisition parameters.
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