Abstract #1928

Multiparametric MRI assessment of botulinum-toxin treatment for a patient with cervical dystonia

Xubin Chai^1,2, Le He¹, Changhao Zhu³, Wanting Hu³, Rong Xue², Xiaolei Song¹, and Li Wang⁴

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, Beijing, China, ²State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ³China School of Information Sciences and Technology, Northwest University, Xi'an, China, ⁴Department of Neurology, The First Hospital of Tsinghua University, Beijing, China

Synopsis

Keywords: Neurodegeneration, Molecular ImagingCervical dystonia (CD) has been regarded as the most common form of focal dystonia, the affected neck muscles always in sustained situation lead to an abnormal rotation of the head[1]. The mechanisms of CD have not yet been thoroughly illustrated. Botulinum toxin (BT)is considered as the recommended first-line therapeutic method for the focal dystonia[2].Traditional MRI Scan has been used to evaluate any pathophysiological changes of brain anatomy or the affected neck muscles[3].However, seldom MRI have provided the cervical muscles metabolic messages[4].The CEST MRI could provide the metabolic aspects of the cervical muscles before and after the treatment of the BT

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