Abstract #1929

Glutathione+γ-Aminobutyric Acid Detection Improves Inter-Subject Concentration Variability at 3T

Jack Knight-Scott¹, Marie Caillaud², Isabelle Gallagher², Yanrong Li², and Andreana P. Haley²

¹Radiology, Children's Healthcare of Atlanta, Atlanta, GA, United States, ²Psychology, The University of Texas at Austin, Austin, TX, United States

Synopsis

Keywords: Neurodegeneration, SpectroscopyQuantification of the combination glutathione (GSH) + γ-aminobutyric acid (GABA) at 3T in medium TE but high signal-noise brain spectra yields a stable concentration with a low coefficient of variation (CV) of only 6%, smaller than individual CV values for GSH or GABA. While an indication of the interdependency of GSH and GABA quantification, [GSH+GABA] also suggests a pathway for the study of perturbations in GABA and GSH at 3T while maintaining the high information content typical of un-edited spectra.

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