Abstract #1937

Intravoxel incoherent motion diffusion weighted imaging to assess brain microstructure and perfusion in patients with end-stage renal disease

Xiangxiang Wu¹, Zijian Jiang¹, Jiahui Zheng¹, Zhuqing Jiao², Tongqiang Liu¹, Weiqiang Dou³, and Haifeng Shi¹

¹Changzhou Second People’s Hospital, Changzhou, China, ²Changzhou University, Changzhou, China, ³GE Healthcare, MR Research China, Beijing, China

Synopsis

Keywords: Neurodegeneration, Diffusion/other diffusion imaging techniquesThis study aimed to investigate the clinical value of intravoxel incoherent motion (IVIM) diffusion-weighted imaging in evaluating the brain microstructural and perfusion changes in end-stage renal disease (ESRD) patients. 40 ESRD patients and 30 healthy subjects were recruited in this study and underwent IVIM MRI. The microstructure and perfusion of the brain showed significantly differences in the left frontal lobe, bilateral temporal lobe, left hippocampus, right occipital lobe, represented by IVIM derived parameters of slow apparent diffusion coefficient (ADC_slow) and fast apparent diffusion coefficient (ADC_fast). Therefore, we concluded that the brain microstructure and perfusion were impaired in ESRD patients.

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