Abstract #1938

Varied hemodynamic and metabolic responses of disease modifying and curative therapies in adults with sickle cell disease

Megan Aumann¹, Jarrod J Eisma¹, Alexander K Song¹, Spencer L Waddle¹, Sky Jones¹, Meher R Juttukonda², Niral J Patel³, Samantha Davis¹, Taylor Davis^1,2, Lori Jordan^1,4, and Manus J Donahue¹

¹Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, ²Radiology, Vanderbilt University Medical Center, Nashville, TN, United States, ³Pediatric Endocrinology and Diabetes, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Pediatrics, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Stroke, Stroke, metabolismTwo common treatment paradigms for sickle cell disease (SCD) include oral medication hydroxyurea and blood transfusions. Rarely, a curative hematopoietic stem cell transplant (HSCT) is performed. We utilized non-invasive MRI to evaluate how potential biomarkers of infarct risk, cerebral blood flow (CBF) and oxygen extraction fraction (OEF), change in these treatment paradigms (cumulative n=39). Hydroxyurea treatment did not have significant changes to hemoglobin, CBF, or OEF between two scans. Hemoglobin increases by approximately 8.73 and 64.11% for adults with SCD on transfusion and transplant treatments, respectively. These changes most prominently parallel a reduction in CBF of 20.46 and 31.67%, respectively.

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