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Abstract #1945

GluCEST MRI at 3.0 T Identifies Glutaminase Alteration in Patients with Stroke

Qin Wen1, Xingke Huang1, Yun Su1, Zhuoheng Yan1, Chen Zhao2, Zhiwei Shen3, Jiaji Mao1, and Jun Shen1
1Department of Radiology, Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University, Guangzhou, China, 2Philips Healthcare, Guangzhou, China, 3Philips Healthcare, Beijing, China

Synopsis

Keywords: Stroke, CEST & MT, GlutamateThis study investigated the feasibility of GluCEST at 3.0 T for detecting the change of glutamate in the human brain after stroke. The imaging capability of glutamate is validated on the phantom and human brain, respectively. Glutamate at physiological concentrations could be detected by in vitro MRI. The findings of an in vivo investigation revealed that the GluCEST signal of stroke patients differs from that of healthy individuals and that this difference may be detected by 3.0 T MRI. This work provides fresh insights into the use of endogenous glutamate MRI imaging.

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