Abstract #1948

Altered static and dynamic spontaneous neural activity in patients with ischemic pontine stroke

Xin Wang¹, Caihong Wang¹, Jingchun Liu², Jun Guo³, Peifang Miao¹, Ying Wei¹, Kaiyu Wang⁴, Jingliang Cheng¹, and Cuiping Ren¹

¹Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China, ³Department of Radiology, Tianjin Huanhu Hospital, Tianjin, China, ⁴MR Research China, GE Healthcare, Beijing, China

Synopsis

Keywords: Stroke, BrainWe aimed to investigate the static and dynamic characteristics of brain activity after stroke by using functional magnetic resonance imaging (fMRI). Seventy-three patients with pontine ischemic stroke and 50 healthy controls (HCs) were recruited and received a resting-state fMRI scanning. Our result shows that there are significantly altered sALFF/dALFF and sReHo/dReHo values in the brain regions of patients. And the alterations of dynamic brain activity in the basal ganglia and cerebellum were correlated with the degree of cognitive impairment. Static and dynamic biomarkers can be combined together to provide more comprehensive information on potential therapeutic targets.

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