Keywords: Stroke, PreclinicalA considerable sex bias exists in preclinical research, with studies on male animals outnumbering those in females, yet several preclinical rodent studies of transient middle cerebral artery occlusion (tMCAO) reported that infarct volume is smaller in females than in males. As the neurochemical profile greatly evolves after stroke, the present study aimed to evaluate whether the neurochemical profile is modified differently between male and female mice post tMCAO. We found that baseline values apart from taurine show no differences as previously reported. However, a difference in the metabolic profile between male and female mice becomes visible after tMCAO.
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