Keywords: Stroke, Ischemia, ischemic stroke, Multi-parametric Z-spectral MRI, lesionsMulti-parametric Z-spectral MRI has been successfully implemented in vivo. In this study, multi-contrast Z-spectra fitted with four Lorentzian functions were acquired from eighteen ischemic stroke patients. We found that this novel method could differentiate lesions from normal brain tissues, and multiple Z-spectral contrasts showed a satisfying correlation with the apparent diffusion coefficient (ADC). Multi-parametric Z-spectral MRI could specifically characterize the metabolic alterations of ischemic brain tissues in stroke patients.
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