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Abstract #1954

Investigating the Use of Statins in a Juvenile Photothrombotic Rat Stroke Model

Daniel Sare1, Daniel Li1, Bryan Kartono1, Adam Waspe2,3, and Andrea Kassner1,3
1Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, 2Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada, 3Department of Medical Imaging, The University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Stroke, BrainPediatric stroke remains a significant cause of lifelong neurological impairment and morbity. Treatment options and our understanding of stroke evolution in the developing brain, especially beyond the peri- and neonatal period, is still limited. By using a photothrombotic juvenile rat stroke model and quantitative MRI, we were able to assess stroke and blood-brain barrier damage following the use of atorvastatin from the hyper acute to chronic stages following acute ischemic stroke. Findings support a reduction in lesion volume within the statin group with no significant changes to BBB damage.

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