Abstract #1957

Association between diffusion-weighted image analysis along the perivascular space index and early-onset post‑stroke cognitive impairment

Hongwei Li¹, Min Chu², Lianlian Liu³, He Wang^1,4,5, and Jing Zhao²

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ²Department of Neurology, Minhang Hospital, Fudan University, Shanghai, China, ³Department of Radiology, Minhang Hospital, Fudan University, Shanghai, China, ⁴Human Phenome Institute, Fudan University, Shanghai, China, ⁵Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China

Synopsis

Keywords: Stroke, NeuroscienceThe mechanism of cognitive impairment following stroke is uncertain. It has been demonstrated that the glymphatic system has an impact on cognitive function, which can be measured by the diffusion weighted image analysis along the perivascular space (DWI-ALPS) index. The purpose of this study was to see whether the DWI-ALPS index was associated with early-onset post-stroke cognitive impairment. Our data revealed that DWI-ALPS index in PSCI group was significantly lower than in non-PSCI group, and it had a good predictive value for PSCI.

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