Abstract #1976

Histogram-based analysis of recurrence pattern correlations with MGMT methylation status in glioblastoma using synthetic MRI and 3D-ASL

Pei Dang¹, Xueying Huang², Xin Ge³, Lidong Wang⁴, Aijun Wang², Minglei Wang², Xuhong Yang⁵, Yuhui Xiong⁶, and Xiaodong Wang⁷

¹Radiology, General Hospital of Ningxia Medical University, yinchuan, China, ²General Hospital of Ningxia Medical University, Yinchuan, China, ³Lanzhou University, Lanzhou, China, ⁴Radiology, Yinchuan Hospital of Traditional Chinese Medicine, Yinchuan, China, ⁵Ningxia Medical University, Yinchuan, China, ⁶GE Healthcare MR Research, Beijing, China, ⁷Radiology, General Hospital of Ningxia Medical University, Yinchuan, China

Synopsis

Keywords: Tumors, Cancer, Glioblastoma; Synthetic MRI; 3D-ASL; Histogram; MGMT; Recurrence patternsAt least 10% of glioblastoma relapses occur at distant and even contralateral locations. This disseminated growth limits surgical intervention and contributes to neurologicalmorbidity.The aim of the present study was to evaluate factors predicting the recurrencepattern determined.The results revealed that the pattern of recurrence in glioblastoma patients after combined radio-chemotherapy treated are strictly correlated with age at diagnosis and MGMT methylation status.Whole-tumor histogram analysis of quantitative parameters from synthetic MRI and 3D-ASL was to evaluate the value of predicting MGMT methylation status .Combining T1_10th, T2_{10th ,}and CBF_entropy may explore as an effective strategy to predict of MGMT methylation status.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.