Abstract #1982

Cardiac Magnetic Resonance Imaging at 3T Characterizes the Myocardium for Pediatric Cardiac Transplant Recipients: New Biomarker Development

Margaret M Samyn¹, Adam M Gordon², Ke Yan³, Jian Zhang⁴, Aspen M Duffin⁵, Jonathan H Soslow⁶, Bruce Damon⁷, Jennifer M Gerardin¹, Benjamin M Goot⁸, Joseph R Cava¹, and Steven J Kindel¹

¹Pediatrics, Medical College of Wisconsin/ Herma Heart Institute at Children's Wisconsin, Milwaukee, WI, United States, ²Medical College of Wisconsin, Milwaukee, WI, United States, ³Pediatrics, Medical College of Wisconsin/ Quantitative Health Sciences, Milwaukee, WI, United States, ⁴Quantitative Health Sciences, Medical College of Wisconsin/ Quantitative Health Sciences, Milwaukee, WI, United States, ⁵Herma Heart Institute, Children's Wisconsin, Milwaukee, WI, United States, ⁶Pediatrics, Vanderbilt Univesity Medical Center, Nashville, TN, United States, ⁷Bioengineering, Carle Foundation Hospital/University of Illinois, Urbana, IL, United States, ⁸Pediatrics (Cardiology), Medical College of Wisconsin/ Herma Heart Institute at Children's Wisconsin, Milwaukee, WI, United States

Synopsis

Keywords: Cardiovascular, Tissue Characterization, Cardiac transplant; 3Tesla; Parametric ImagingPediatric heart transplant recipients undergo frequent invasive cardiac catheterization with endomyocardial biopsy for routine allograft surveillance. Risks associated with catheterization and sampling error call into question this accepted “gold standard.” Cardiac magnetic resonance imaging (CMR), with parametric imaging, may advance myocardial surveillance in this population. Fifty-two pediatric patients (transplanted at ≤18 years old) underwent CMR (September 2016 to June 2019) at 3T to evaluate myocardial health using MOLLI sequence. Healthy transplant recipients had normal global biventricular function, native T1 higher than published values for healthy children at 3T with similar extracellular volume (ECV) despite history of treated rejection.

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