Abstract #1985

Comparison of 3D Ultra-short Echo Time (UTE) Phase-Resolved Functional Lung (PREFUL) with Hyperpolarized 129Xe MRI in Pediatric Cystic Fibrosis

Samal Munidasa^1,2, Brandon Zanette^1,2, Marie-Pier Dumas³, Wallace Wee³, Jacky Au³, Sharon Braganza¹, Daniel Li¹, Felix Ratjen³, and Giles Santyr^1,2

¹Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada

Synopsis

Keywords: Data Processing, Lung2D phase-resolved functional lung (PREFUL) MRI has been shown to correlate with hyperpolarized Xenon MRI (Xe-MRI) in pediatric Cystic Fibrosis (CF) lung disease but ventilation defects may be missed using the 2D approach. In this study we develop a 3D ultra-short echo time (UTE) PREFUL MRI method and compare to 2D PREFUL MRI and Xe-MRI in CF. 3D UTE PREFUL MRI showed a lower bias between Xe-MRI as compared to 2D PREFUL and was able to detect ventilation defects missed by the 2D approach, suggesting that the 3D approach may be a more comprehensive measure of ventilation in pediatric CF.

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