Abstract #1990

Volumetric flow assessment in fetal sheep with Cartesian 4D flow MRI and radial slice-to-volume flow MRI with and without blood pool contrast

Datta Singh Goolaub¹, Judd Storrs², John Kelly^3,4, Ramkumar Krishnamurthy², Karen Texter⁵, James Strainic⁶, Ellie Ragsdale⁷, Christopher Breuer³, Aimee Armstrong⁴, Rajesh Krishnamurthy², and Christopher K. Macgowan^1,8

¹Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ²Radiology, Nationwide Children’s Hospital, Columbus, OH, United States, ³Center for Regenerative Medicine, Nationwide Children’s Hospital, Columbus, OH, United States, ⁴Cardiology, Nationwide Children’s Hospital, Columbus, OH, United States, ⁵The Heart Center, Nationwide Children’s Hospital, Columbus, OH, United States, ⁶Pediatrics, University Hospitals Rainbow Babies & Children’s Hospital, Cleveland, OH, United States, ⁷OB/GYN-Maternal Fetal Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, ⁸Medical Biophysics, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Fetal, FetusWe compare flow distributions in fetal sheep obtained with Cartesian 4D flow MRI and slice-to-volume multidimensional blood flow imaging using accelerated multislice radial phase contrast MRI. In the latter, stacks of 2D slices are imaged. Real-time reconstructions allow for in-plane motion correction. CINEs are combined into a dynamic flow sensitive volume using slice-to-volume reconstruction with interslice motion correction. Comparison is performed in the presence and absence of contrast agent.

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