Abstract #2019
Pulseq-gSlider: Scanner-independent high-isotropic-resolution dMRI on an open-source platform
Qiang Liu1,2, Lipeng Ning1, Congyu Liao3,4, Shaik Imam5, Scott Peltier6, Borjan Gagoski7, Berkin Bilgic8,9,10, William A. Grissom5, Maxim Zaitsev11, Jon-Fredrik Nielsen12, and Yogesh Rathi1,13
1Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, 2School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 3Department of Radiology, Stanford University, Stanford, CA, United States, 4Department of Electrical Engineering, Stanford University, Stanford, CA, United States, 5Institute of Imaging Science, Department of Biomedical Engineering, Department of Electrical Engineering, Vanderbilt University, Nashville, TN, United States, 6Functional MRI Laboratory, University of Michigan, Ann Arbor, MI, United States, 7Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States, 8Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 9Department of Radiology, Harvard Medical School, Cambridge, MA, United States, 10Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 11Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany, 12Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, 13Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States
Synopsis
Keywords: Data Acquisition, Software ToolsUsing on the open-source pulse sequence programming platform Pulseq, we successfully developed and implemented the gSlider sequence on a 3T scanner without the vendor-specific sequence development environment. One-millimeter whole-brain isotropic dMRI data was acquired using the gSlider implementation from Pulseq and Siemens and test-retest variability was evaluated. The test-retest reliability in fractional anisotropy improved dramatically for the Pulseq implementation while it was comparable for both implementations for mean diffusivity. We demonstrated the feasibility of implementing advanced sequences using the open-source Pulseq platform and expect that it will be easily transferred to and executed on different vendors.
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