Abstract #2021

Visualization of Perivascular Spaces using an Optimized 3D-TSE Sequence with Reduced Flip Angle at 7T

Gael Saib¹, Zeynep Demir¹, Paul Taylor², S. Lalith Talagala³, and Alan P. Koretsky¹

¹NINDS/LFMI, National Institutes of Health, Bethesda, MD, United States, ²NIMH/SSCC, National Institutes of Health, Bethesda, MD, United States, ³NINDS/NMRF, National Institutes of Health, Bethesda, MD, United States

Synopsis

Keywords: Visualization, Neurofluids, CSFPerivascular spaces (PVS) dilatation has been recently linked to aging and neurodegenerative diseases. T₂-weighted ultra-high field MRI allows to image the PVS burden at high contrast and spatial resolution non-invasively. However, most of sub-voxel sized PVS cannot be resolved due to partial volume effects and remaining signal from blood and tissue. High-resolution 3D-TSE with reduced flip angle allowed the visualization of PVS with a very high CSF-to-tissue ratio of ~37:1 at 7T.

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