Abstract #2025

A robust method for estimating CVR dynamics from breath-hold BOLD data without end-tidal carbon dioxide recordings

Nuwan D. Nanayakkara¹, Liesel-Ann Meusel¹, Nicole D. Anderson^1,2, and J. Jean Chen^1,3,4

¹Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada, ²Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON, Canada, ³Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁴Department of Biomedical Engineering, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Data Analysis, fMRI (task based), Cerebrovascular reactivity, CVRCerebrovascular reactivity (CVR) can be estimated from the BOLD response to a vasoactive stimulus such as a breath-holding (BH) approximated by a sinusoidal regressor. We proposed a robust approach for estimating CVR using the frequency spectrum of BOLD data itself, without regressions or correlations with external recordings. We also estimated regional CVR time delay patterns using the BOLD signal phase relative to a non-brain reference. We demonstrate our pipeline in 18 healthy adults.

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