Abstract #2028

Assessing the robustness of the correlation between intra-axonal T2 and axon diameter across participants

Veronica P Dell'Acqua¹, Chantal M W Tax^1,2, Malwina Molendowska¹, Greg D Parker¹, Derek K Jones^1,3, Muhamed Barakovic^1,4,5,6,7, and Erick Jorge Canales-Rodriguez⁶

¹Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom, ²University Medical Center Utrecht, Image Sciences Institute, Utrecht, Netherlands, ³Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia, ⁴Translational Imaging in Neurology (ThINk) Basel, University Hospital Basel and University of Basel, Basel, Switzerland, ⁵MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital Basel and University of Basel, Basel, Switzerland, ⁶Signal Processing Laboratory 5 (LTS5), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁷Roche Pharma Research & Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland

Synopsis

Keywords: Data Analysis, Relaxometry, Validation, Axon Diameter, Diffusion-RelaxationIn-vivo quantification of axon diameter is an attractive and debated topic in the MRI community. The possibility to resolve submicrometric axon diameters non-invasively yields the potential to push further the boundaries in research and clinics but yet, further work is needed to better explore and validate the existing approaches to estimate the inner axon diameter. Recently, the feasibility of estimating the axon diameter from the intra-axonal transverse relaxation time has been investigated combining a diffusion-relaxation protocol and histological data. In the present study, we apply this approach in a larger in vivo population to assess variability across participants.

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