Abstract #2039

Magnetic Resonance Elastography: A Comparison with Virtual Diffusion Derived Elastography

Jonatan Eriksson^1,2, Wolf Bartholomä^2,3, Nils Dahlström^2,3, Jens Tellman^1,2, Stergios Kechagias⁴, Patrik Nasr⁴, Mattias Ekstedt^2,4, Peter Lundberg^1,2, and Johan Kihlberg^2,3

¹Department of Medical Radiation Physics, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden, ²Center for Medical Imaging Science and Visualization, Linköping University, Linköping, Sweden, ³Department of Radiology in Linköping and Department of Health Medicine and Caring Sciences, Linköping University, Linköping, Sweden, ⁴Division of Diagnostics and Specialist Medicine, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden, Linköping, Sweden

Synopsis

Keywords: Liver, Elastography, MRE, DiffusionA virtual manner of determining apparent stiffness values from diffusion images, so called ‘vMRE’, was evaluated in this study which included both healthy subjects and patients with Non-Alcoholic Fatty Liver Disease (NAFLD). No association was observed between true MR-Elastography (MRE) and vMRE. However, the difference between MRE and vMRE was more strongly correlated with T2*. Iron deposition is not uncommon in patients with NAFLD, and for that reason, a spin echo-MRE sequence was used, instead of the gradient-based sequence that has been used previously. Iron deposition in liver shortens T2*, which can also affect diffusion images and the vMRE.

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