Abstract #2045

Harmonized multi-site MRI-based quantification of human liver fat and stiffness: a pilot study

Maninder Singh¹, Owen T Carmichael¹, Adil Bashir², Anne M Russel³, Mark Bolding⁴, David T Redden³, Judd Storr⁵, William R Willoughby⁶, Candace Howard Claudio⁵, Daniel S Hsia⁷, Robert P Kimberly⁸, Meagan E Gray⁶, Eric Ravussin^7,9, and Thomas S Denny²

¹Biomedical Imaging Center, Pennington Biomedical Research Center, Baton Rouge, LA, United States, ²Auburn University, Auburn, AL, United States, ³University of Alabama, Birmingham, AL, United States, ⁴University of Alabama Medical Center, Birmingham, AL, United States, ⁵The University of Mississippi Medical Center, Jackson, MS, United States, ⁶The University of Alabama Medical Center, Birmingham, AL, United States, ⁷Pennington Biomedical Research Center, Baton Rouge, LA, United States, ⁸The University of Alabama School of Medicine, Birmingham, AL, United States, ⁹The University of Alabama, Birmingham, AL, United States

Synopsis

Keywords: Liver, Liver, Nonalcoholic Fatty Liver Disease; Magnetic Resonance Spectroscopy; Elasticity Imaging Techniques; Magnetic Resonance Imaging Non-alcoholic fatty liver disease (NAFLD) is a leading cause of end-stage liver disease. NAFLD diagnosis and follow-up relies on a combination of clinical data, liver imaging, and/or liver biopsy. However, inter-site imaging differences impede diagnostic consistency and reduce the repeatability of the multi-site clinical trials necessary to develop effective treatments. The goal of this pilot study was to harmonize commercially available 3T magnetic resonance imaging (MRI) measurements of liver fat and stiffness in human participants across academic sites and MRI vendors.

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