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Abstract #2049

MR-based segmental quantification of hepatic lipid content in patients with suspected iron overload

Arthur Peter Wunderlich1,2, Holger Cario3, Stephan Kannengießer4, Veronika Grunau1, Michael Götz2, Meinrad Beer1, and Stefan Andreas Schmidt1
1Diagnostic and Intervnetional Radiology, Ulm University, Medical Center, Ulm, Germany, 2Section for Experimental Radiology, Ulm University, Medical Center, Ulm, Germany, 3Department of Pediatrics and Adolescent Medicine, Ulm University, Medical Center, Ulm, Germany, 4MRI Development, Siemens Healthcare GmbH, Erlangen, Germany

Synopsis

Keywords: Liver, Fat, segmental hepatic fat distribution

Purpose

To investigate the segmental distribution of hepatic fat fraction in hematologic patients.

Methods

The liver of 44 patients examined with 3D MR multi-echo gradient-echo was segmented semiautomatically and subdivided into nine segments. Segmental fat content was determined on PDFF maps and tested for statistically significant differences.

Results

Highly significant differences were detected. Segments 1 to 3 had the highest fat content, segments 7 and 8 the lowest.

Conclusions

Our results suggest that liver segments may represent functional aspects in fat metabolism and/or storage in addition to their anatomical significance. Fat distribution in hematologic patients was similar to living donors.

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