Abstract #2055

Liver R2* with magnitude fitting in iron-overload patients – initial results on agreement between protocol settings and between 1.5T and 3T

Stephan A.R. Kannengiesser¹, Arthur P. Wunderlich^2,3, Xiaodong Zhong⁴, Dominik Nickel¹, Holger Cario⁵, Michael Götz^2,3, Meinrad Beer³, and Stefan A. Schmidt²

¹MR Application Pevelopment, Siemens Healthcare GmbH, Erlangen, Germany, ²Department of Diagnostic and Interventional Radiology, Ulm University Medical Center, Ulm, Germany, ³Section for Experimental Radiology, Ulm University Medical Center, Ulm, Germany, ⁴MR R&D Collaborations, Siemens Medical Solutions, Inc., Los Angeles, CA, United States, ⁵Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany

Synopsis

Keywords: Liver, Quantitative Imaging, R2*, iron content

Purpose: Preliminary liver R2* comparison in patients across field strengths and protocols.

Methods: 3T R2* from 3D multi-gradient echo data with magnitude fitting was mapped to 1.5T R2*. Limits of agreement were calculated.

Results: Converted 3T R2* agreed well with 1.5T R2*. Best 95% limits of agreement were [-4.9% 7.6%] for 1.5T R2* [166s^-1 865s^-1] and [-34.5% 41.7%] for [49s^-1. 865s^-1].

Conclusion: 3T R2* agrees well with 1.5T R2* and can be used interchangeably for 3T R2* between 328s^-1 and 1699s^-1 with an optimized protocol. For low R2* values, protocols with longer echo times should be used.

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