Abstract #2056

Feasibility of Prostate MR Fingerprinting and ADC Mapping in the quantitative characterization of malignant transition zone lesions

Anna Lavrova¹, Ananya Panda², Sarah E. Wido³, Lee Ponsky³, Maria Masotti⁴, Thomas Chenevert¹, Yun Jiang¹, Leonardo Kayat Bittencourt⁵, Anupama Ramachandran¹, Katherine Wright¹, Nicole Seiberlich¹, Hero Hussain¹, and Vikas Gulani¹

¹Department of Radiology, University of Michigan, Ann Arbor, MI, United States, ²Department of Diagnostic and Interventional Radiology, All Indi Institute of Medical Sciences, Jodhpur, India, ³Department of Urology, Case Western Reserve University, Cleveland, OH, United States, ⁴Department of Biostatistics, University of Michigan, Ann Arbor, MI, United States, ⁵Department of Radiology, Case Western Reserve University, Cleveland, OH, United States

Synopsis

Keywords: Prostate, CancerThe purpose of this study is to assess the feasibility of the use of MR Fingerprinting combined with ADC mapping for characterizing prostate transition zone (TZ) cancers. This quantitative approach has shown promising results in differentiating prostate cancer from normal prostate tissue in peripheral and transition zones, and in separating low from intermediate/high grade tumors in the PZ. Our study aimed to confirm previous observations of quantitative differences in T1, T2 and ADC between cancers and normal appearing TZ, and to assess the utility of MRF-derived T1 and T2 mapping in distinguishing low grade lesions from high/intermediate-grade cancers in TZ.

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