Abstract #2086

Quantitative Microstructure Mapping of Head and Neck Squamous Cell Carcinoma Using Time-Dependent Diffusion MRI: A Preliminary Study

Hangzhi Liu¹, Xinyan Wang¹, Chen Zhang², Thorsten Feiweier³, Xiaohong Chen⁴, and Junfang Xian¹

¹Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China, Beijing, China, ²MR collaborations, Siemens Healthcare, Beijing, China, Beijing, China, ³Siemens Healthcare GmbH,Neurology Applications Development, Erlangen, Germany, Erlangen, Germany, ⁴Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, China, Beijing, China

Synopsis

Keywords: Head & Neck/ENT, Head & Neck/ENTThis study investigated the feasibility of IMPULSED(Imaging Microstructural Parameters Using Limited Spectrally Edited Diffusion) to evaluate cell microstructure of head and neck squamous cell carcinoma. The results showed that mean cell diameter, extracellular diffusion coefficient and intracellular volume fraction are 9.47±3.33 µm,1.95±1.04μm²/ms and 0.23±0.14% respectively and consistent with the previous pathological reports. Patients with cervical lymph node metastases had significantly smaller mean cell diameters than those without metastases. Mean cell diameter decreased with increasing cycles of immunotherapy. This suggests that IMPULSED can quantitatively characterize cell properties of tumor in head and neck squamous cell carcinoma patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.