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Abstract #2087

Correlation between magnetic resonance perfusion and Ki-67 expression in nasopharyngeal carcinoma

Nan Wang 1, Lijun Wang1, Lizhi Xie2, and Ailian Liu1
1Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China, 2GE Healthcare, MR Research China, Beijing, China

Synopsis

Keywords: Sparse & Low-Rank Models, CancerNasopharyngeal carcinoma (NPC) is a common malignancy in Southeast Asia. In this study, we explore the correlation between the quantitative parameters derived from dynamic contrast-enhanced magnetic resonance (DCE-MRI) of NPC with Ki-67 index. Results showed that the Ktrans mean was positively correlated with Ki-67. The Ktrans mean value was significantly higher in cases with a high Ki-67 status than in those with a low Ki-67 status (AUC 0.8519), and the cutoff value, sensitivity, and specificity was 0.479, 77.78%, and 100%, respectively, suggesting the Ktrans parameter of DCE-MRI has the most utility in distinguishing between high and low Ki-67 levels.

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