Abstract #2091

Ultra High Spatial Resolution MRI of Intact Ex Vivo Multiple Sclerosis Brain

Ken Sakaie¹, Jagjit Sidhu¹, Kedar Mahajan^2,3, Kunio Nakamura⁴, Daniel Ontaneda², Bruce Trapp³, Mark J. Lowe¹, Stephen Jones¹, and Emmanuel Obusez¹

¹Imaging Institute, The Cleveland Clinic, Cleveland, OH, United States, ²Mellen Center, The Cleveland Clinic, Cleveland, OH, United States, ³Neurosciences, The Cleveland Clinic, Cleveland, OH, United States, ⁴Biomedical Engineering, The Cleveland Clinic, Cleveland, OH, United States

Synopsis

Keywords: Multiple Sclerosis, Multiple SclerosisTreatment options for progressive multiple sclerosis (MS) are limited and the lack of sensitive and specific MRI biomarkers is a major hurdle in therapeutic development. A number of pathophysiological processes are repeatedly found on histology but are difficult to identify accurately on MRI. Ultra-high spatial resolution MRI of intact ex vivo brain promises to help bridge the gap between MRI and pathology. We demonstrate progress towards visualizing potential biomarkers for progressive MS.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.