Abstract #2093

Association of longitudinal changes in cerebral microstructure with cognitive function in breast cancer survivors after adjuvant chemotherapy

Yi-Fang Wu¹, Vincent Chin-Hung Chen^2,3, Yuan-Hsiung Tsai^2,4, and Jun-Cheng Weng^1,3,5

¹Department of Medical Imaging and Radiological Sciences, and Department of Artificial Intelligence, Chang Gung University, Taoyuan, Taiwan, ²School of Medicine, Chang Gung University, Taoyuan, Taiwan, ³Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁴Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁵Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan

Synopsis

Keywords: Neuroinflammation, CancerAdjuvant chemotherapy for breast cancer might impact cognitive function and brain structure. In this study, we investigated the cerebral microstructural changes in breast cancer survivors after adjuvant chemotherapy and the correlation with cognitive function with longitudinal study designs. The results showed brain volume reduction in thefrontal and temporal regions were also observed in patients from baseline to postchemotherapy. An association between brain volume and cognitive performance was also found in the limbic system. According to our findings, the study was useful in developing a prediction model as well as a guide for cancer treatment.

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