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Abstract #2096

Flow augmentation after occlusion maintains functional connectivity and mean diffusivity

Chisondi Simba Warioba1, Mira Liu1, Sean Foxley1, Julian Bertini1, Gregory Christoforidis2, and Timothy Carroll1
1Radiology, University of Chicago, Chicago, IL, United States, 2Mount Carmel, Columbus, OH, United States

Synopsis

Keywords: Stroke, fMRI (resting state)Through the use of resting state functional MRI, diffusion tensor imaging (DTI), and a unique canine stroke model, our study explored the functional and structural effects of maintaining perfusion pressure as a means of extending the window of opportunity for thrombectomy. In our preliminary results, the employment of flow augmentation indicated a maintenance of functional connectivity, mean T2* signal intensity, and mean diffusivity in the ischemic region. Through this we have shown a potential method of extending the "door-to-needle time" in stroke treatment and possible therapeutic effects of flow augmentation therapy in acute stroke.

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Keywords