Abstract #2097

Diffuse dural sinus hyperintensities on arterial spin labeling reflects reduced cerebral metabolic rate of oxygen in sickle cell anemia patients

Alexander K. Song^1,2, Spencer L. Waddle³, Randall Sky Jones⁴, Niral J. Patel⁴, Samantha Davis⁴, Chelsea Custer¹, Larry Taylor Davis³, Sumit Pruthi³, Jarrod J. Eisma¹, Megan A. Aumann¹, Lori C. Jordan⁴, and Manus J. Donahue¹

¹Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, ²Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, United States, ³Radiology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Stroke, StrokeSickle cell anemia (SCA) patients have elevated cerebral blood flow and flow velocities to partially compensate for reduced blood oxygen content; this phenomenon may result in inefficient oxygen delivery to tissue due to accelerated red cell capillary transit. Pseudo-continuous arterial spin labeling (pCASL) and T₂-relaxation-under-sping-tagging (TRUST) MRI methods were used to assess arterial-to-venous transit artifacts and oxygen metabolism in 150 SCA participants. Patients with diffuse dural sinus hyperintensities on pCASL had 22.7% lower cerebral metabolic rates of oxygen compared to their counterparts; however, values remained within a normal range of 2.91±0.69 ml O₂/100g/min and were not associated with infarct history.

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