Abstract #2099

Progressive Lactic Acidosis is Associated with Infarct Growth Volume in Acute Ischemic Stroke: A Longitudinal 3D MRSI Study

Bin Bo¹, Tianyao Wang², Ziyu Meng¹, Yibo Zhao^3,4, Yudu Li^3,5, Rong Guo^3,6, Wen Jin^3,4, Xin Yu⁷, Zhi-Pei Liang^3,4, and Yao Li¹

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, ³Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁶Siemens Medical Solutions USA, Inc., Urbana, IL, United States, ⁷Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Synopsis

Keywords: Stroke, Spectroscopy

Imaging lactic acidosis is of significance for injury assessment in acute stroke. In this study, we investigated the progression of lactate, along with the concomitant changes in N-acetylaspartate and creatine concentrations, and its relationship to infarct growth using high-resolution MRSI data acquired from a longitudinal cohort of 42 ischemic stroke patients. The results showed that the progression in lactate level was predictive of infarct growth volume from acute to subacute stroke. Our study might provide a useful biomarker for lactic acidosis and tissue injury assessment in ischemic stroke.

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