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Abstract #2102

Assessing cerebral oxygen metabolism changes in preeclampsia using voxel-based morphometry of oxygen extraction fraction (OEF) maps in MRI

Chaofan Sui1, Qihao Zhang2, Junghun Cho2, Linfeng Yang3, Tao Chen3, Bin Guo3, Kelly M. Gillen2, Jing Li4, Lingfei Guo1, and Yi Wang2
1Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, 2Department of Radiology, Weill Cornell Medical College, New York, NY, United States, 3Department of Radiology, Jinan Maternal and Child Care Hospital, Jinan, China, 4Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China

Synopsis

Keywords: Stroke, HypertensionThe objective of this study was to analyze the different brain oxygen metabolism statuses in preeclampsia. Furthermore, we also investigated the influencing factors that affect cerebral oxygen metabolism in preeclampsia. Forty-nine preeclampsia patients, forty nonpregnant healthy controls (NPHCs) and twenty-two pregnant healthy controls (PHCs) were included in this study. Brain OEF values were computed using quantitative susceptibility mapping (QSM) plus quantitative blood oxygen level‐dependent magnitude-based OEF mapping (QSM+qBOLD, or QQ). Voxel-based morphometry (VBM) was applied to investigate the differences of OEF values in brain regions among groups.

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