Abstract #2103

Ultra-high field MRI sequences for clot characterization in acute ischemic stroke

Karl-Olof Lövblad^1,2, Daniela Dumitriu LaGrange², Lijing Xin³, Philippe Reymond², Seàn Fitzgerald⁴, Karen M. Doyle^4,5, Paolo Machi^1,2, Maria Isabel Vargas^1,2, François Lazeyras^2,3, and Isabel Wanke^6,7,8

¹Division of Diagnostic and Interventional Neuroradiology, HUG Geneva University Hospitals, Geneva, Switzerland, ²Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland, ³Ecole Polytechnique Fédérale de Lausanne (EPFL), Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, ⁴Department of Physiology, University of Galway, Galway, Ireland, ⁵CURAM, Sciene Foundation Ireland (SFI) Centre for Research in Medical Devices, University of Galway, Galway, Ireland, ⁶Division of Neuroradiology, Klinik Hirslanden, Zurich, Switzerland, ⁷Swiss Neuroradiology Institute, Zurich, Switzerland, ⁸Division of Neuroradiology, University of Essen, Essen, Germany

Synopsis

Keywords: Stroke, StrokeIn acute ischemic stroke, the composition of the clot occluding the arteries is associated with the underlying pathophysiology and with the response to treatment. Innovative MRI sequences aim to improve the ability to recognize clot composition from neuroimaging signs. Using ultra-high field MR imaging of clot analogs, we demonstrate the ability of R2* map to distinguish between red blood cells-rich and fibrin-rich compositions. This technique can also be used for the volumetric analysis of formalin fixed clots. Further studies with intermediate clot compositions and improved phantoms will reveal the full potential of MRI sequences for depicting clot composition.

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