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Abstract #2125

Automatic Segmentation of Vasculature in DCE-MRI of Brain Tumors and its Influence in Grading

Anshika Kesari1, Virendra Kumar Yadav1, Raufiya Jafari1, Rakesh Kumar Gupta2, Rana Patir3, Sandeep Vaishya3, Sunita Ahlawat4, and Anup Singh1,5,6
1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, 2Department of Radiology, Fortis Memorial Research Institute, Gurugram, India, 3Department of Neurosurgery, Fortis Memorial Research Institute, Gurugram, India, 4SRL Diagnostics, Fortis Memorial Research Institute, Gurugram, India, 5Yardi School for Artificial Intelligence, Indian Institute of Technology Delhi, New Delhi, India, 6Department of Biomedical Engineering, All India Institute of Medical Sciences, New Delhi, India

Synopsis

Keywords: Tumors, Brain Quantitative DCE-MRI parameters are sensitive to tumor microvasculature and have shown potential in tumor grading. Generally, value of some of these parameters increases with tumor grades. During analysis of tumor region, large-blood-vessels (LBV) can influence the actual changes due to tumor microvasculature and hence provide erroneous results. Objectives of this study were to develop an automatic framework for segmentation of the LBV present within and outside of the tumor region and to reduce errors in tumor grading. The statistical analysis of parameters in tumor region showed significant differences between with and without LBV. Moreover, LBV removal improved tumor classification accuracy.

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Keywords