Abstract #2131

Comparative Evaluation of Metabolite Composition in Brain Tumor Epilepsy Patients

Natasha Najam¹, Steven Tobochnik², Huijin Liao¹, Sanghoon Kim¹, Jong Woo Lee², and Alexander Lin¹

¹Center for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital , Harvard Medical School, Boston, MA, United States, ²Department of Neurology, Brigham and Women's Hospital , Harvard Medical School,, Boston, MA, United States

Synopsis

Keywords: Tumors, Spectroscopy, Brain Tumor-Related Epilepsy, Isocitrate Dehydrogenase MutationBrain Tumor Related Epilepsy (BTRE) is a multi-factorial condition with unclear pathophysiology. It has a robust prevalence in tumor patients with 20-40% experiencing onset seizures and a further 20-45% experiencing refractory seizures to treatment.¹ This work examines the tumor microenvironment using magnetic resonance spectroscopy (MRS) to learn more about the epileptogenic mechanisms through a comparison of metabolite composition in BTRE patients and non-seizure tumor patients. Increasing knowledge about the pathophysiology of BTRE might aid the management of anti-tumor and BTRE treatment in the future.

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