Abstract #2135

Self-Navigated Rapid Radial Free-Breathing Liver MR Elastography: Assessment of Technical Performance in Children at 3T

Sevgi Gokce Kafali^1,2, Bradley D. Bolster Jr.³, Shu-Fu Shih^1,2, Timoteo I. Delgado^1,4, Xiaodong Zhong⁵, Vibhas Deshpande⁶, Timothy R. Adamos⁷, Shahnaz Ghahremani^1,7, Kara L. Calkins⁷, and Holden H. Wu^1,2,4

¹Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ²Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, Los Angeles, CA, United States, ³US MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Salt Lake City, UT, United States, ⁴Physics and Biology in Medicine Interdepartmental Program, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁵US MR Collaborations, Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States, ⁶US MR Collaborations, Siemens Medical Solutions USA, Inc., Austin, TX, United States, ⁷Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States

Synopsis

Keywords: Elastography, LiverHepatic stiffness measured by MR elastography (MRE) is a biomarker for fibrosis. Standard liver MRE requires breath-holding (BH) to avoid motion artifacts, but BH is challenging for children. Radial free-breathing (FB) MRE can overcome this challenge but requires longer scan times. Radial FB-MRE using rapid wave encoding decreases the scan time and self-navigation supports motion compensation. With the help of fractional encoding to reduce echo times, image quality can be further improved. This work demonstrated that self-navigated rapid and rapid fractional FB-MRE methods measure hepatic stiffness with close agreement and similar repeatability compared to corresponding BH-MRE in children at 3T.

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