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Abstract #2150

Magnetic resonance and diffusion tensor imaging of the adolescent rabbit growth plate of the knee

Ola Kvist1, Peter Damberg1, Zelong Dou1, Johan Sanmartin Berglund2, Carl-erik Flodmark3, Ola Nilsson1,4, and Sandra Diaz Ruiz1,3
1Karolinska Institute, Stockholm, Sweden, 2Blekinge Institute of Technology, Stockholm, Sweden, 3Lunds University, Malmö, Sweden, 4Örebro University, Örebro, Sweden

Synopsis

Keywords: Cartilage, Diffusion Tensor ImagingThe hindlimbs of female rabbits aged 16, 20, and 24 weeks were studied in a 9.4T MRI scanner to assess the ability of MRI-DTI to evaluate growth plate morphology and activity compared with that of histomorphometry and micro-computed tomography (μCT) in rabbits. The MRI sequences included a multi-gradient echo 3D sequence and DTI in 14 directions (b-value= 984 s/mm2). The growth plate height and volume were similar for all modalities at each time point and age. Tract number and volume declined with age; however, tract length did not show any changes. MRI-DTI may be useful for evaluating the growth plates.

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Keywords