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Abstract #2155

SSL-QALAS: Self-Supervised Learning for Multiparametric Quantitative MRI Using QALAS

Yohan Jun1,2, Jaejin Cho1,2, Xiaoqing Wang1,2, Michael Gee2,3, P. Ellen Grant2,4, Berkin Bilgic1,2,5, and Borjan Gagoski2,4
1Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 4Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children’s Hospital, Boston, MA, United States, 5Harvard/MIT Health Sciences and Technology, Cambridge, MA, United States

Synopsis

Keywords: Quantitative Imaging, Quantitative ImagingThe 3D-quantification using an interleaved Look-Locker acquisition sequence with T2 preparation pulse (3D-QALAS) has been developed and used for acquiring high-resolution T1, T2, and PD maps from five measurements. The dictionary matching method can be used for generating quantitative maps from the acquired multi-contrast images; however, it requires an external dictionary, which needs to be pre-calculated and voxel-by-voxel fitting is computationally demanding. In this study, we propose to generate multiple quantitative maps including T1, T2, PD, and inversion efficiency (IE) maps using self-supervised learning from 3D-QALAS measurements (i.e., SSL-QALAS) for rapid, accurate, and dictionary-free multiparametric fitting.

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Keywords