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Abstract #2156

Investigating the Accuracy of PD Measurements at 3T

Zach Lun Pang1, Maria Schmidt2, Evanthia Kousi2, and Julie Hughes3
1Medical Physics, St George’s University Hospitals NHS Foundation Trust, London, United Kingdom, 2Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, United Kingdom, 3The Royal Marsden NHS Foundation Trust, London, United Kingdom

Synopsis

Keywords: Phantoms, Quantitative ImagingWe investigated the accuracy of clinical proton density (PD) mapping employing the variable flip-angle (VFA) method at 3T, considering the effects of B1+ and B1- fields. Following B1+ correction, the PD measurements were within 5% of the expected value for flip-angle variations up to 18%. Considerable discrepancies were observed for T1<300ms and flip-angle variations >25%. Using image intensity filters, considerable PD variations were found at the edges of the test object. Clinically, the B1+ and B1- corrected PD values of the brain were similar to values reported in the literature, rendering the VFA method a viable tool for PD mapping.

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Keywords