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Abstract #2157

Normative brain atlas of T2/T1 relaxometry ratio for detection of microstructural pathology

Veronica Ravano1,2,3, Samuele Caneschi1,2,3, Jan Krasensky4, Michaela Andelova5, Matej Kudrna4, Tomas Uher5, Gian Franco Piredda1,6,7, Jonathan Disselhorst1,2,3, Bénédicte Maréchal1,2,3, Jean-Philippe Thiran2,3, Jonas Richiardi2, Manuela Vaneckova4, Tom Hilbert1,2,3, and Tobias Kober1,2,3
1Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, 2Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 3LTS5, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 4Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic, 5Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University, Prague, Czech Republic, 6Human Neuroscience Platform, Fondation Campus Biotech Geneva, Geneva, Switzerland, 7CIBM-AIT, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Synopsis

Keywords: Quantitative Imaging, Tissue Characterization, Neuroinflammation; NeurodegenerationQuantitative MRI allows the characterization and comparison of microstructural tissue properties and, by defining normative ranges for healthy tissue, detection of pathology. The simultaneous evaluation of multiple qMRI measures facilitates the understanding of what biological mechanisms underlie the observed deviations in relaxometry. Here, we introduce the ratio between quantitative T2 and T1 maps (T2/T1) as a microstructural property whose deviations from normative values could be predictive or characteristic of brain pathologies. A T2/T1 voxel-wise normative atlas was created and allowed characterization of tissue changes in two multiple sclerosis patients, providing complementary information to the existing T1 and T2 atlases.

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