Abstract #2164

Finding Precise, Direct, and Personalized Landmarks of Deep Brain Stimulus Tremor Targeting on Advanced MR imaging

Sohae Chung^1,2, Ha Neul Song³, Yvonne W. Lui^1,2, Brian H. Kopell³, and Ki Sueng Choi³

¹Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Nash Family Center for Advanced Circuit Therapeutics, Ichan School of Medicine at Mount Sinai, New York, NY, United States

Synopsis

Keywords: Quantitative Imaging, Quantitative Susceptibility mapping, Tremor

Deep brain stimulation (DBS) is an efficacious treatment for tremors. The clinical outcome is critically dependent on precisely personalized targeting, yet localization of DBS target remains challenging owing to difficulties in resolving individual thalamic nuclei or dentato-rubro-thalamic (DRT) pathways. Here we investigated retrospectively to identify neurosurgical landmarks of DBS targeting by examining the volume overlap and centroid distance between DBS contacts and DRT delineated from quantitative susceptibility imaging. Our findings show a significantly higher volume overlap of DBS contacts with DRT in the good-response tremor group, showing potential of our approach as a direct and personalized neurosurgical guidance tool.

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