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Abstract #2175

A New Framework for 3D MR Fingerprinting with Efficient Subspace Reconstruction and Joint Posterior Distribution Estimation

Jiaren Zou1,2, Yuchi Liu3, Jesse Hamilton2,3, Yun Jiang2,3, Nicole Seiberlich2,3, and Yue Cao1,2,3
1Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States, 2Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, 3Department of Radiology, University of Michigan, Ann Arbor, MI, United States

Synopsis

Keywords: MR Fingerprinting/Synthetic MR, MR Fingerprinting

Iterative image reconstruction of highly undersampled high-resolution 3D MR fingerprinting (MRF) is time-consuming and has high memory requirements. In this work, we propose to use stochastic gradient descent to accelerate the reconstruction and reduce the memory footprint. In addition, a conditional invertible neural network is used as a fast and flexible tool for estimating the posterior distribution of tissue properties from MRF. In a simulation study, we achieved an 11-fold and 45.5GB reduction in reconstruction time and memory requirement, respectively, compared with a conventional iterative method. Uncertainty maps of tissue properties derived from the estimated posterior distributions correlate well with reconstruction errors.

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Keywords