Abstract #2177

Enhancing the precision of multi-phase parametric maps in 4D-MRF by optimization of local T1 and T2 sensitivities

Yat Lam Wong¹, Tian Li¹, Chenyang Liu¹, Victor Ho Fun Lee², Lai Yin Andy Cheung³, Peng Cao⁴, Edward Sai Kam Hui⁵, and Jing Cai¹

¹Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, Hong Kong, ²Department of Clinical Oncology, The University of Hong Kong, Hong Kong, Hong Kong, ³Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, Hong Kong, ⁴Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ⁵The Chinese University of Hong Kong, Hong Kong, Hong Kong

Synopsis

Keywords: MR Fingerprinting/Synthetic MR, MR FingerprintingTime-resolved magnetic resonance fingerprinting (MRF), or 4D-MRF, has demonstrated its feasibility in motion management in radiotherapy (RT). However, the prohibitive long acquisition time is one of challenges of the clinical implementation of 4D-MRF. The shortening of acquisition time may compromise the accuracies of the predicted tissues’ properties. Here, we propose a novel technique to enhance the accuracies of 4D-MRF with shortened acquisition by optimizing T1 and T2 sensitivities through inter-phase data sharing.

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