Abstract #2196

Snapshot CEST at 3T using 3D True FISP

Yupeng Wu¹, Zhichao Wang², Qifan Pang¹, Gaiying Li¹, Mengying Chen¹, Xu Yan³, Caixia Fu⁴, Yang Song³, and Jianqi Li¹

¹Shanghai key lab of magnetic resonance, East China Normal University, Shanghai, China, ²Zhejiang Lab, Hangzhou, China, ³MR Scientific Marketing, Siemens Healthineers, Shanghai, China, ⁴MR Application Development, Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China

Synopsis

Keywords: Pulse Sequence Design, CEST & MT, GRE FLASH TrueFISPFor clinical implementation, chemical exchange saturation transfer (CEST) imaging must be fast with high signal‐to‐noise ratio (SNR), 3D coverage, and produce robust contrast. In general, CEST imaging with fast low angle shot GRE sequence (FLASH) can achieve fast acquisition, but may yield low SNR efficiency. This study evaluated APT and NOE maps for single saturation 3D CEST imaging with True FISP and FLASH sequences, respectively. We found that True FISP could achieve better SNR of Z-spectrum and obtain more reliable CEST effects contrast. 3D True FISP sequence is expected to become a more promising 3D CEST-GRE sequence for clinical application.

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