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Abstract #2200

Decoding of 3T and 7T bSSFP profile asymmetries for T1, T2, and fraction quantification in two-compartment systems

Nils Marc Joel Plähn1, Adèle Mackowiak2, Berk Açikgöz3, and Jessica Bastiaansen3
1Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern Universit, Bern, Switzerland, 2Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 3Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

Synopsis

Keywords: Data Analysis, High-Field MRI, phase-cycled bSSFP, Aceton fraction quantificationA novel Off-Resonant encoded Analytical parameter quantification using Complex Linearized Equations (ORACLE) method using phase-cycled bSSFP profiles was developed. The approach decodes complex asymmetry profiles in multi-compartment systems for simultaneous proton fraction, T1/T2 ratio, T1 and T2 quantification. The approach was validated in simulations and in an acetone-water phantom at 3T and 7T. Simulations and experiments validated the proposed method for multi-parameter quantification using phase-cycled bSSFP for two compartment singlet systems with high accuracy and precision. This provides the first step towards proton fraction quantification of more complex multiplet-systems, such as fat or myelin, exploiting complex asymmetry profiles.

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