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Abstract #2202

VUDU-SAGE: Efficient T2 and T2* Mapping using Joint Reconstruction for Motion-Robust, Distortion-Free, Multi-Shot, Multi-Echo EPI

Jaejin Cho1,2, Tae Hyung Kim3, Avery JL Berman4, Yohan Jun1,2, Xiaoqing Wang1,2, Borjan Gagoski2,5, and Berkin Bilgic1,2,6
1Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Computer Engineering, Hongik University, Seoul, Korea, Republic of, 4Carleton University, Ottawa, ON, Canada, 5Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children’s Hospital, Boston, MA, United States, 6Harvard/MIT Health Sciences and Technology, Cambridge, MA, United States

Synopsis

Keywords: Data Acquisition, Quantitative Imaging, T2 and T2* mappingWe demonstrate T2 and T2* mapping and joint reconstruction for multi-echo, multi-shot EPI data from a variable flip angle, blip-up and -down undersampling (VUDU) for spin and gradient echo (SAGE) acquisition. VUDU-SAGE employs a blip-up and -down acquisition strategy for correcting B0 distortion, and FLEET-ordering for motion-robust multi-shot EPI while maximizing signal using variable flip angles. VUDU-SAGE acquires five echoes consisting of two gradient-echo, two mixed, and one spin-echo contrasts. We jointly reconstruct all echoes and estimate T2 and T2* maps using Bloch dictionary matching. In-vivo experiment presents T2 and T2* map at 1x1x4mm3 resolution with a 9-second acquisition.

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