Keywords: Pulse Sequence Design, PhantomsIntracranial atherosclerotic disease (ICAD) is a leading cause of preventable ischemic stroke. Long-term management of chronic ICAD would benefit from directly quantifying key risk factors, such as the oxygen extraction fraction (OEF) and cerebrovascular reserve (CVR). The accurate measurement of the phase signal is vital to measuring OEF using MRI and seeing these effects through the cardiac cycle promises to elucidate CVR. A cardiac-gated, multi-shot, multi-echo rosette pulse sequence is developed and validated with simulation and a phantom study. The proposed pulse sequence and reconstruction pipeline produces strong off-resonance frequency measurements with a scan time under two minutes.
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