Abstract #2228

Reduction of artifacts and background signals in ex vivo mouse embryo MRI by potato starch suspension

Tomokazu Tsurugizawa^1,2,3, Takuma Kumamoto⁴, and Yoshichika Yoshioka^3,5

¹Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, ²Faculty of Engineering, University of Tsukuba, Tsukuba, Japan, ³Center for Information and Neural Networks (CiNet), Osaka University and National Institute of Information and Communications Technology (NICT), Osaka, Japan, ⁴Developmental Neuroscience Project, Department of Brain & Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, ⁵Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan

Synopsis

Keywords: Data Acquisition, Ex-Vivo ApplicationsThe high-field MRI enables to investigate the microstructure in the mouse embryo. The proton-free fluid is used for the surrounding liquid around the specimen in MR-microimaging, but the potential issue of the image quality remains due to the air bubbles on the edge of the specimen and the motion artifact. Here, we demonstrated that the potato starch suspension with phosphate-buffered saline showed a low T1 and T2 signal intensity and strongly prevent the motion of the embryo during the scanning. These results indicate the utility of potato starch suspension for MR-microimaging of mouse embryos.

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